Protein Construction Kit Passes First Tests
Artificial protein compounds developed by the Institute of Bioorganic Chemistry (IBC, Moscow) have passed preclinical tests. The protein construction kit may be used for cancer treatment and detection.
“Our principle, comments Sergey Deev, Head of Molecular Immunology Laboratory , IBC, is to provide self-assembly of proteins that know one another with high degree of precision. By changing the protein part of construction, the drug may be delivered to the target types of cells depending on the disease. We assemble the molecular constructor in blocks, which will enable construction of a specific drug for each individual patient with cancer with account of the stage of disease, which is particularly important, as cancer cells undergo fast mutations”.
The researcher also remarked that besides protein, that provides target delivery, an agent may be connected to the module, which may kill a cancer or other pathogenic cell: a toxine, radionuclide, chemotherapeutic compound, antibacterial agent etc. So the new method is suitable for treatment of cancers but also neurodegenerative and infectious disorders. And if a fluorescent molecule or a magnetic mark is connected to the module, the method may also be used for detection.
Clinical trials in mice with induced human tumors (breast cancer and ovarian cancer) have been completed. The studies have shown that the method works and does not cause systemic toxicity.
The next step will include clinical trials of the new method. But it will be on the agenda of medical community.