Drug from Wood
Chemists from Irkutsk have developed a new drug. From the waste products of wood, discarded by timber operators, at Irkutsk Institute of Chemistry, Siberian District, RAS, Agsular substance was obtained, which passed preclinical studies, which showed efficacy of that semi-synthetic heparinoid as hypolipidemic and anticoagulant agent. Besides, it has been proven that the study compound is slightly toxic (IV class of hazard, LD50 > 5 g/kg), it is characterized by a wide therapeutic spectrum and is safe for long-term (90 days) daily intragastric or oral administration to investigational warm-blooded animals (rodents and dogs). Besides, it does not have irritative effects on gastrointestinal mucosa, does not provoke allergic reactions, does not have negative impact on reproductive function and does not have mutagenic or carcinogenic effects, i.e. it is safe, as it is free of delayed adverse effects.
Forthcoming clinical trials require significant costs, both financial and temporal. But it is worth the effort, for in all the world significant resources are needed to develop drugs against atherosclerosis and scientists from Irkutsk suggested a simple and inexpensive way of obtaining such a drug from our local cheap raw materials.