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Chemists from the Moscow Physico-Technological Institute and RAS Institutes have developed a method of obtaining glasiovianin A and its structural analogs, inhibiting growth of cancer cells using  cheap herbal raw materials – fennel and parsley seed.

Researchers from the Moscow Physico-Technological Institute in Dolgoprudniy Alexander Kiselev and their colleagues have found a cheap way to synthesize the substance using a compound,  contained in large amounts in fennel and parsley seeds.

Drugs preventing growth and division of neoplastic cells, so-called antimitotics, degrade tubulin – one of the basic cell proteins, critically important for division. Such substances were synthesized or found in tropical plant tissues. The Russian variant of assembly of molecules of the antineoplastic drug is less expensive both because of wide-spread raw materials, and fewer synthesis steps and catalysers used.

Besides glaziovianin A Russian chemists have developed several structural analogs of the compound in search of new antimitotic agents. Their antineoplastic activity was tested in echinus embryos and in human neoplastic cells. By the way, the use of echinus embryos is another innovation, for such cells divide fast at early stages of development, imitating the tumor growth process. If an antimitotic is added to the culture medium where they are found, echinus begin to swirl, which helps assess the potency of new drugs, their tenacity and side effects.

Reseachers think that two glasiovianin similar are promising for further use in medicine, although glasiovianin A has shown the highest antineoplastic activity.

Next studies will be performed in laboratory mice  human tumor cells transplants.

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