A Molecule Protecting Against Stroke
The problem of brain protection against stroke is being investigated at Tomsk Polytechnic University. The study is performed by employees of laboratory for the study of neuroprotection mechanisms at RASA Center, Tomsk Polytechnic University in cooperation with colleagues from American Center of Cardiovascular Studies ad Cardiology Department at the Central Massachusetts Hospital (Harvard School of Medicine).
The cooperation resulted in opening of a new compound protecting the brain from consequences of ischemic and reperfusion lesions. The compound in question is oxime – an organic dual action compound – nitrogen oxide (NO) donor and c-Jun N-terminal kinase (JNK) inhibitor. Administration of the drug promotes nitrogen oxide emission playing an important role in the human body.
Nitrogen oxide is an important molecule involved in the body vital functions. In the blood vessel walls nitrogen oxide is produced by endothelial cells, participating in the vascular tone control, blood flow and blood pressure regulation.
This research has long-standing prospects and will be continued at the Laboratory for protection of neuroprotection mechanisms at the basis of the Tomsk Polytechnic University Science Park. The new substance may be used both for treatment of ischemia and stroke and to lower the risks of these conditions in patients with vascular disorder.
Besides employees of the Tomsk Polytechnic University and Harvard University the project involves researchers from the E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center, RAS; Montana State University, Altay State Technical University and Baltic Federal University.