New Compound to Overcome Outcomes of Stroke
A team of chemists at the Tomsk Polytechnic University is developing a new drug intended to protect the brain against consequences of stroke.
The team is working over a double acting organic compound: nitrogen oxide (NO) donor and c-Jun N-trminal kinase (JNK) inhibitor. Administration of that compound induces production of nitrogen oxide playing an important role in the body functions. Endothelial cells produce nitrogen oxide in the blood vessel walls. Nitrogen oxide ensures preservation of the vascular tonus, regulation of blood circulation and blood pressure in the human body.
Experiments proved that mice receiving a therapeutic dose of the above-mentioned drug, had lower neurological disorders and decreased size of nercosis areas at the site of brain lesion as early as in 48 hours after ischaemia/reperfusion. This agent is suggested to be able to treat consequences of ischaemia and stroke, and at the same time help reduce risks of their occurrence in patients with vascular disorders.
An application for patent has already been submitted. The study of properties of the new substance at Tomsk Polytechnic University will be continued.