Tablets or Insulin Injections?
The Diabetes, Obesity and Metabolism journal published in the UK, presenting scientific publications in endocrinology, including diabetes, has published results of a study assessing effects of insulin and hypoglycemic oral drugs.
The authors of the publication have been studying the data on almost 22 thousand patients with type 2 diabetes, who underwent therapy with insulin or inhibitors of sodium dependent type 2 glucose co-transporter and dipeptidil peptidase 4 inhibitors. The study has shown that oral hypoglycemic drugs are safer than insulin. These products provided a 44%, 15% and 74% decrease of overall lethality, cardiovascular morbidity and hypoglycemia.
Dipeptidil peptidase-4 inhibitors (DPP-4) lower the high blood glucose level by increasing insulin production due to increased level of increatines, thanks to the drugs. Inhibitors of sodium dependent glucose cotransporter 2 lower blood glucose level through insulin-independent decrease of glucose reabsorption in renal tubuli, i.e. inducing its urinary excretion.